Brendan James Keating, DPhil

"International Efforts in Transplantation Genomics: Large Research Cohorts"


September 7, 2018 | 2:00 to 3:00 p.m. | 1-451 Moos Tower

Brendan Keating, D.Phil., studied molecular genetics at the Department of Clinical Medicine at University of Oxford, with his Ph.D. lab work completed in the Wellcome Trust. He completed a post-doctoral fellowship at the Institute of Translational Medicine and Therapeutics at UPenn, and was a visiting Scientist at the Wellcome Trust Sanger Institute. Dr. Keating designed and developed genomic tools for cardiovascular-related studies that have been used in over 200,000 DNA samples across 60 studies. His major research interests focus on the analyses of miRNA, mRNA and polymorphisms of donor and recipients genomes in heart, liver, lung and kidney transplantation, with the aim of delivering individualized treatment of immunosuppression therapies, and detection of genetic signals that underpin graft rejection and complications of rejection. Dr. Keating is Principal Investigator of genome-wide association studies for solid-organ transplant studies within the Children’s Hospital of Philadelphia. He is also a member of the pharmacogenomics and return of results working groups of the NHGRI electronic medical record and genomics (eMERGE) network, which is integrating clinical genetic data into patient’s electronic medical records for clinical decision support in the individualized dosing of patients for a range of therapeutics.